Oral immunotherapy (OIT) effectively controls food allergy. This study used a murine OIT model to explore the underlying mechanisms, focusing on the transition from desensitization to allergy regulation. Researchers found that desensitized mast cells (MCs) exhibited beneficial alterations, including increased regulatory cytokine induction and enhanced regulatory T cell (Treg) expansion. Importantly, Treg-mediated inhibition of allergic responses was significantly reduced in MC-deficient mice. The findings suggest that inducing regulatory MCs is a novel therapeutic strategy for allergic diseases.
