logo
ResearchBunny Logo
Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy

Medicine and Health

Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy

Y. Takasato, Y. Kurashima, et al.

Discover how oral immunotherapy (OIT) can transform the management of food allergies! This research by Yoshihiro Takasato and colleagues reveals that desensitized mast cells enhance regulatory T cell expansion, paving the way for innovative therapeutic strategies against allergic diseases.

00:00
00:00
Playback language: English
Abstract
Oral immunotherapy (OIT) effectively controls food allergy. This study used a murine OIT model to explore the underlying mechanisms, focusing on the transition from desensitization to allergy regulation. Researchers found that desensitized mast cells (MCs) exhibited beneficial alterations, including increased regulatory cytokine induction and enhanced regulatory T cell (Treg) expansion. Importantly, Treg-mediated inhibition of allergic responses was significantly reduced in MC-deficient mice. The findings suggest that inducing regulatory MCs is a novel therapeutic strategy for allergic diseases.
Publisher
Mucosal Immunology
Published On
Dec 10, 2020
Authors
Yoshihiro Takasato, Yosuke Kurashima, Masahiro Kiuchi, Kiyoshi Hirahara, Sayuri Murasaki, Fujimi Arai, Kumi Izawa, Ayako Kaitani, Kaoru Shimada, Yukari Saito, Shota Toyoshima, Miho Nakamura, Kumiko Fujisawa, Yoshimichi Okayama, Jun Kunisawa, Masato Kubo, Naoki Takemura, Satoshi Uematsu, Shizuo Akira, Jiro Kitaura, Takao Takahashi, Toshinori Nakayama, Hiroshi Kiyono
Tags
oral immunotherapy
food allergy
regulatory mast cells
regulatory T cells
desensitization
allergy regulation
cytokine induction

Related Publications

Explore these studies to deepen your understanding of the subject.

Factors associated with the outcomes of a novel virtual reality therapy for military veterans with PTSD: Theory development using a mixed methods analysis
Psychology

Factors associated with the outcomes of a novel virtual reality therapy for military veterans with PTSD: Theory development using a mixed methods analysis

B. Hannigan, R. V. Deursen, et al.

Exogenous metabolite application is a potential strategy for expanding the use of direct rice seeding with the aim of reducing seeding costs
Agriculture

Exogenous metabolite application is a potential strategy for expanding the use of direct rice seeding with the aim of reducing seeding costs

B. Qing, Y. Jiang, et al.

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)
Medicine and Health

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)

A. J. M. Aabakke, T. G. Petersen, et al.

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Medicine and Health

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

G. 2. D. Collaborators, D. Kanyin, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny