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Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain

Biology

Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain

B. Xu, H. Shimauchi-ohtaki, et al.

This groundbreaking research by Bin Xu, Hiroya Shimauchi-Ohtaki, Yuhei Yoshimoto, Tetsushi Sadakata, and Yasuki Ishizaki reveals how transplanting human iVECs can transform outcomes in ischemic stroke models, particularly by enhancing the recruitment of regulatory T cells and promoting myelin regeneration. Dive into the fascinating interplay between cellular therapies and neuroinflammation!

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Playback language: English
Abstract
Ischemic stroke in the brain's white matter causes demyelination and neuroinflammation. Regulatory T cells (Tregs) infiltrate the ischemic brain, modulating inflammation. This study investigated whether transplanting human induced pluripotent stem cell-derived vascular endothelial cells (iVECs) improves white matter infarcts by influencing Tregs. iVECs and Tregs were transplanted into ischemic white matter. Fingolimod (FTY720), which sequesters lymphocytes in lymph nodes, was used to assess the role of peripheral immune cells. iVEC transplantation reduced inflammatory cells and CD4+ T cells while increasing Tregs. FTY720 suppressed neuroinflammation but not remyelination. iVEC transplantation increased Tregs from the periphery, and this Treg recruitment was crucial for remyelination. Transplanting Tregs with iVECs in FTY720-treated animals significantly improved myelin regeneration.
Publisher
Journal of Neuroinflammation
Published On
Jan 01, 2023
Authors
Bin Xu, Hiroya Shimauchi-Ohtaki, Yuhei Yoshimoto, Tetsushi Sadakata, Yasuki Ishizaki
Tags
ischemic stroke
white matter
regulatory T cells
demyelination
neuroinflammation
iVEC transplantation
remyelination
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