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High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

Medicine and Health

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

H. Xu, L. Zhong, et al.

This groundbreaking study explores the role of oral mucosa in the 2019-nCoV infection pathway, highlighting the significant expression of ACE2 in tongue epithelial cells. Conducted by esteemed researchers Hao Xu, Liang Zhong, Jiaxion Deng, Jiakuan Peng, Hongxia Dan, Xin Zeng, Taiwen Li, and Qianming Chen, the findings suggest that the oral cavity may be a critical area for infection risk.

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Playback language: English
Abstract
This study investigated the potential of oral mucosa as a route for 2019-nCoV infection by analyzing ACE2 expression. Using RNA-seq data from TCGA and FANTOMS CAGE databases and in-house single-cell transcriptomes, the researchers found that ACE2 is expressed in the oral mucosa, particularly highly enriched in tongue epithelial cells. This suggests that the oral cavity might be a high-risk site for 2019-nCoV infection.
Publisher
International Journal of Oral Science
Published On
Feb 24, 2020
Authors
Hao Xu, Liang Zhong, Jiaxion Deng, Jiakuan Peng, Hongxia Dan, Xin Zeng, Taiwen Li, Qianming Chen
Tags
2019-nCoV
oral mucosa
ACE2 expression
tongue epithelial cells
infection pathway
RNA-seq data

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