Current soft neural probes are limited by bulky, rigid electronics. This paper introduces a soft, conformable neural interface system that monitors single-unit neuronal activities with long-term stability. The system uses soft neural probes implanted in the brain and electronics printed directly onto the cranial surface using high-resolution liquid metal printing. In vivo studies in mice demonstrate long-term (33 weeks) neural activity recording and behavior-induced neuronal activation in multiple brain regions.
Publisher
Nature Communications
Published On
Feb 27, 2024
Authors
Young-Geun Park, Yong Won Kwon, Chin Su Koh, Enji Kim, Dong Ha Lee, Sumin Kim, Jongmin Mun, Yeon-Mi Hong, Sanghoon Lee, Ju-Young Kim, Jae-Hyun Lee, Hyun Ho Jung, Jinwoo Cheon, Jin Woo Chang, Jang-Ung Park
Tags
soft neural probes
neural interface
neuronal activity
long-term stability
high-resolution printing
in vivo studies
brain regions
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