Medicine and Health

Hic-5 is required for activation of pancreatic stellate cells and development of pancreatic fibrosis in chronic pancreatitis

L. Gao, X. Lei, et al.

Discover how activated pancreatic stellate cells (PSCs) contribute to pancreatic fibrosis in chronic pancreatitis (CP) through the exciting role of Hic-5, a TGF-β1-induced protein. This groundbreaking study by Lin Gao, Xiao-Feng Lei, and colleagues reveals that targeting Hic-5 may lead to novel therapies for CP by inhibiting PSC activation and pancreatic fibrosis.

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Playback language: English

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Abstract

Activated pancreatic stellate cells (PSCs) are the main source of extracellular matrix proteins in pancreatic fibrosis during chronic pancreatitis (CP). This study investigated the role of Hic-5, a TGF-β1-induced protein, in PSC activation and CP development. Hic-5 expression was significantly upregulated in activated PSCs from human CP tissue and a caerulein-induced mouse CP model. Hic-5 deficiency attenuated pancreatic fibrosis and PSC activation in mice. Mechanistically, Hic-5 knockdown inhibited the TGF-β/Smad2 signaling pathway, reducing collagen production and α-SMA expression. The study suggests Hic-5 as a potential marker of activated PSCs and a therapeutic target for CP.

Publisher

Scientific Reports

Published On

Nov 05, 2020

Authors

Lin Gao, Xiao-Feng Lei, Aya Miyauchi, Masahito Noguchi, Tomokatsu Omoto, Shogo Haraguchi, Takuro Miyazaki, Akira Miyazaki, Joo-ri Kim-Kaneyama

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