Medicine and Health

Health and disease markers correlate with gut microbiome composition across thousands of people

O. Manor, C. L. Dai, et al.

This groundbreaking study from Ohad Manor and colleagues unravels the complex relationships between gut microbiota and various host phenotypic features across thousands of individuals. With findings indicating significant variance in the gut microbiome and potential microbiome-targeted interventions, this research opens new doors for enhancing host health.

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Abstract

This study investigates the associations between gut microbiota and ~150 host phenotypic features in ~3,400 individuals. Key findings include the identification of major taxonomic variance axes in the gut microbiome, a putative diversity maximum along the Firmicutes-to-Bacteroidetes axis, and both known and unknown associations between microbiome composition and host clinical markers and lifestyle factors. These results suggest potential for microbiome-targeted interventions to improve host health.

Publisher

Nature Communications

Published On

Oct 27, 2020

Authors

Ohad Manor, Chengzhen L Dai, Sergey A Kornilov, Brett Smith, Nathan D Price, Jennifer C Lovejoy, Sean M Gibbons, Andrew T Magis

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