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Abstract
This randomized controlled trial investigates the effects of intermittent fasting combined with protein pacing (IF-P) versus continuous caloric restriction (CR) on gut microbiome (GM) and metabolomic profiles in overweight/obese individuals. IF-P (n=21) showed improved gut symptoms, increased abundance of *Christensenellaceae* microbes, and higher circulating cytokines and amino acids promoting fat oxidation compared to CR (n=20). CR showed increased metabolites associated with longevity. These differences highlight the role of GM and metabolomic factors in weight loss maintenance and body composition.
Publisher
Nature Communications
Published On
May 28, 2024
Authors
Alex E. Mohr, Karen L. Sweazea, Devin A. Bowes, Paniz Jasbi, Corrie M. Whisner, Dorothy D. Sears, Rosa Krajmalnik-Brown, Yan Jin, Haiwei Gu, Judith Klein-Seetharaman, Karen M. Arciero, Eric Gumpricht, Paul J. Arciero
Tags
intermittent fasting
protein pacing
gut microbiome
metabolomic profiles
caloric restriction
weight loss
overweight

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