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Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression

Medicine and Health

Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression

M. Luo, Q. Wang, et al.

This exciting research by Man Luo and colleagues explores the impact of a 4-day fasting-mimicking diet on colorectal cancer in mice. The study reveals that this diet not only suppresses cancer growth but also enhances immune response and gut microbiota, particularly highlighting the role of *Lactobacillus johnsonii* in these effects. Discover how combining this diet with anti-PD-1 therapy could revolutionize CRC treatment!

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Playback language: English
Abstract
This study investigated the therapeutic effect of a 4-day fasting-mimicking diet (FMD) against colorectal cancer (CRC) in mice. FMD cycles suppressed CRC growth, reduced cell proliferation and angiogenesis, and increased tumor-infiltrating lymphocytes, especially CD8⁺T cells. FMD stimulated protective gut microbiota, particularly *Lactobacillus*. *Lactobacillus johnsonii* supplementation mimicked FMD's effects, suppressing tumor growth and increasing CD45⁺ and CD8⁺ T cells. Combining FMD with anti-PD-1 therapy further inhibited CRC progression. These findings suggest *Lactobacillus johnsonii* is crucial for FMD's anticancer effects in CRC, acting through gut microbiota and immune system modulation.
Publisher
npj Biofilms and Microbiomes
Published On
Jun 25, 2024
Authors
Man Luo, Qingyi Wang, Yong Sun, Yao Jiang, Qiwen Wang, Yanrou Gu, Zhefang Hu, Qianyi Chen, Jilei Xu, Shujie Chen, Tongyao Hou, Lijun Feng
Tags
fasting-mimicking diet
colorectal cancer
Lactobacillus johnsonii
immune modulation
tumor growth
gut microbiota

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