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Gut Microbiome Wellness Index 2 enhances health status prediction from gut microbiome taxonomic profiles

Medicine and Health

Gut Microbiome Wellness Index 2 enhances health status prediction from gut microbiome taxonomic profiles

D. Chang, V. K. Gupta, et al.

Discover the innovative Gut Microbiome Wellness Index 2 (GMWI2), which offers a revolutionary approach to assess gut health using microbial taxonomic profiles. This research, conducted by a team of experts including Daniel Chang and Vinod K. Gupta, demonstrates GMWI2's impressive accuracy in distinguishing between healthy and non-healthy individuals, establishing it as a vital tool for health evaluation.

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Playback language: English
Abstract
This paper introduces Gut Microbiome Wellness Index 2 (GMWI2), an improved version of GMWI, designed as a disease-agnostic health status indicator based on gut microbiome taxonomic profiles. Analysis of 8069 stool shotgun metagenomes from 54 studies showed GMWI2 achieved 80% cross-validation balanced accuracy in distinguishing healthy from non-healthy individuals, exceeding the original GMWI and traditional α-diversity indices. Inter-study and external validation maintained ~75% accuracy. GMWI2, available as an open-source tool, provides a resource for evaluating health using individual gut microbial composition.
Publisher
Nature Communications
Published On
Aug 28, 2024
Authors
Daniel Chang, Vinod K. Gupta, Benjamin Hur, Sergio Cobo-López, Kevin Y. Cunningham, Nam Soo Han, Insuk Lee, Vanessa L. Kronzer, Levi M. Teigen, Lioudmila V. Karnatovskaia, Erin E. Longbrake, John M. Davis III, Heidi Nelson, Jaeyun Sung
Tags
Gut Microbiome
Health Indicator
Taxonomic Profiles
Metagenomics
Biodiversity
Accuracy

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