Medicine and Health

Gut microbial and human genetic signatures of inflammatory bowel disease increase risk of comorbid mental disorders

J. Lee, S. J. Oh, et al.

This intriguing study by Junho Lee and colleagues delves into the interplay between inflammatory bowel disease (IBD) and comorbid mental disorders (CMD), revealing a significant link between gut microbiome diversity and mental health in IBD patients. With genetic insights and the identification of specific microbial taxa, this research sheds light on how gut dysbiosis could elevate CMD risks among IBD sufferers.

00:00

Playback language: English

Index

Abstract

This study investigates the relationship between inflammatory bowel disease (IBD) and comorbid mental disorders (CMDs) by analyzing human genetic variants, gut microbiome, and anxiety/depression estimates in 507 IBD patients and 75 controls. IBD patients, particularly those with CMD, showed lower gut microbial diversity. 106 differentially abundant taxa (DATs) were identified in IBD patients compared to controls, and 21 DATs distinguished CMD-affected from CMD-free IBD patients. Microbial IBD-risk scores were significantly higher in CMD-affected patients. An IBD-risk variant potentially regulating a DAT associated with both IBD and CMD suggests a genetic-microbial interplay. The study highlights the role of gut dysbiosis in increasing CMD risk in IBD patients, partly through genetic mechanisms.

Publisher

npj Genomic Medicine

Published On

Oct 29, 2024

Authors

Junho Lee, Shin Ju Oh, Eunji Ha, Ga Young Shin, Hyo Jong Kim, Kwangwoo Kim, Chang Kyun Lee

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

A pilot randomized controlled trial investigating the effects of an anti-inflammatory dietary pattern on disease activity, symptoms and microbiota profile in adults with inflammatory bowel disease

A. Marsh, V. Chachay, et al.

Medicine and Health

Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

J. Zhou, M. Li, et al.

Medicine and Health

Body composition, physical activity, and quality of life in pediatric patients with inflammatory bowel disease on anti-TNF therapy—an observational follow-up study

K. K. Boros, G. Veres, et al.

Medicine and Health

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)

A. J. M. Aabakke, T. G. Petersen, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny