This study investigates the relationship between inflammatory bowel disease (IBD) and comorbid mental disorders (CMDs) by analyzing human genetic variants, gut microbiome, and anxiety/depression estimates in 507 IBD patients and 75 controls. IBD patients, particularly those with CMD, showed lower gut microbial diversity. 106 differentially abundant taxa (DATs) were identified in IBD patients compared to controls, and 21 DATs distinguished CMD-affected from CMD-free IBD patients. Microbial IBD-risk scores were significantly higher in CMD-affected patients. An IBD-risk variant potentially regulating a DAT associated with both IBD and CMD suggests a genetic-microbial interplay. The study highlights the role of gut dysbiosis in increasing CMD risk in IBD patients, partly through genetic mechanisms.
Publisher
npj Genomic Medicine
Published On
Oct 29, 2024
Authors
Junho Lee, Shin Ju Oh, Eunji Ha, Ga Young Shin, Hyo Jong Kim, Kwangwoo Kim, Chang Kyun Lee
Tags
inflammatory bowel disease
comorbid mental disorders
gut microbiome
genetic variants
mental health
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