Veterinary Science

Genome-wide association study to identify genomic regions and positional candidate genes associated with male fertility in beef cattle

H. Sweett, P. A. S. Fonseca, et al.

Explore groundbreaking research on bull fertility conducted by H. Sweett, P. A. S. Fonseca, A. Suárez-Vega, A. Livernois, F. Miglior, and A. Cánovas. This study unveils significant genomic regions and candidate genes linked to fertility traits like scrotal circumference and sperm motility, paving the way for enhancing breeding strategies in beef cattle.

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Abstract

This research aimed to identify genomic regions and positional candidate genes associated with bull fertility in beef cattle. A GWAS using a weighted single-step genomic BLUP approach was performed on 265 crossbred beef bulls to identify markers associated with scrotal circumference (SC) and sperm motility (SM). Eight windows (32 genes) and five windows (28 genes) explained >1% of genetic variance for SC and SM, respectively. Functional analysis revealed 14 prioritized genes for SC (including previously identified fertility genes MAP3K1 and VIP) and 14 for SM (including SOD2, TCP1, PACRG, SPEF2, PRLR). Significant enrichment for fertility and body conformation QTLs was observed. The identified regions contribute to understanding fertility traits and identifying candidate genes for further investigation.

Publisher

Scientific Reports

Published On

Nov 18, 2020

Authors

H. Sweett, P. A. S. Fonseca, A. Suárez-Vega, A. Livernois, F. Miglior, A. Cánovas

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