Veterinary Science

Genome-wide association study to identify genomic regions and positional candidate genes associated with male fertility in beef cattle

H. Sweett, P. A. S. Fonseca, et al.

Explore groundbreaking research on bull fertility conducted by H. Sweett, P. A. S. Fonseca, A. Suárez-Vega, A. Livernois, F. Miglior, and A. Cánovas. This study unveils significant genomic regions and candidate genes linked to fertility traits like scrotal circumference and sperm motility, paving the way for enhancing breeding strategies in beef cattle.

00:00

Playback language: English

Index

Abstract

This research aimed to identify genomic regions and positional candidate genes associated with bull fertility in beef cattle. A GWAS using a weighted single-step genomic BLUP approach was performed on 265 crossbred beef bulls to identify markers associated with scrotal circumference (SC) and sperm motility (SM). Eight windows (32 genes) and five windows (28 genes) explained >1% of genetic variance for SC and SM, respectively. Functional analysis revealed 14 prioritized genes for SC (including previously identified fertility genes MAP3K1 and VIP) and 14 for SM (including SOD2, TCP1, PACRG, SPEF2, PRLR). Significant enrichment for fertility and body conformation QTLs was observed. The identified regions contribute to understanding fertility traits and identifying candidate genes for further investigation.

Publisher

Scientific Reports

Published On

Nov 18, 2020

Authors

H. Sweett, P. A. S. Fonseca, A. Suárez-Vega, A. Livernois, F. Miglior, A. Cánovas

Related Publications

Explore these studies to deepen your understanding of the subject.

Agriculture

Genome-wide association study uncovers genomic regions associated with grain iron, zinc and protein content in pearl millet

M. Pujar, S. Gangaprasad, et al.

Medicine and Health

DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity

P. Baca, F. Barajas-olmos, et al.

Medicine and Health

Joint association of sleep quality and physical activity with metabolic dysfunction-associated fatty liver disease: a population-based cross-sectional study in Western China

Y. Wang, Q. Zhao, et al.

Linguistics and Languages

A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children

Y. Lin, Y. Shi, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny