Medicine and Health

Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation

M. Cho, J. Han, et al.

This study presents an innovative bioresorbable flexible hybrid opto-electronic system for real-time electrophysiological recording and optogenetic stimulation, showcasing exceptional biocompatibility and efficacy in transgenic mice. Conducted by a collaborative team, this research paves the way for transformative biomedicine applications.

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Abstract

This study introduces a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation. The device, composed of biodegradable materials, has a direct optical and electrical interface with the brain, exhibiting excellent biocompatibility. Chronically implanted in transgenic mice, it successfully photostimulated the somatosensory area while recording local field potentials. This system promises versatile applications in biomedicine.

Publisher

Nature Communications

Published On

Mar 06, 2024

Authors

Myeongki Cho, Jeong-Kyu Han, Jungmin Suh, Jeong Jin Kim, Jae Ryun Ryu, In Sik Min, Mingyu Sang, Selin Lim, Tae Soo Kim, Kyubeen Kim, Kyowon Kang, Kyuhyun Hwang, Kanghwan Kim, Eun-Bin Hong, Min-Ho Nam, Jongbaeg Kim, Young Min Song, Gil Ju Lee, Il-Joo Cho, Ki Jun Yu

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