Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

This paper introduces a flexible and fully implantable wireless optoelectronic system for continuous and effective cancer treatment by combining photodynamic therapy (PDT) and hyperthermia, and enabling real-time tumor size monitoring. The system uses micro inorganic light-emitting diodes (µ-LEDs) emitting 624 nm light with programmable intensity and a Si phototransistor for tumor size monitoring. In vitro experiments, ray-tracing simulations, and in vivo studies using a tumor xenograft mouse model confirmed the system's superior capabilities in simultaneous cancer treatment and tumor size monitoring via wireless power and data transmission with a cell phone. This all-in-one system enables effective treatment of deep tumors and precise, continuous monitoring.

Kiho Kim, In Sik Min, Tae Hee Kim, Do Hyeon Kim, Seungwon Hwang, Kyowon Kang, Kyubeen Kim, Sangun Park, Jongmin Lee, Young Uk Cho, Jung Woo Lee, Woon-Hong Yeo, Young Min Song, Youngmee Jung, Ki Jun Yu