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Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

Medicine and Health

Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

K. Kim, I. S. Min, et al.

Explore a groundbreaking wireless optoelectronic system designed for effective cancer treatment that merges photodynamic therapy and hyperthermia with real-time tumor monitoring. Developed by an innovative team of researchers, this system not only targets deep tumors but also allows for precise and continuous tracking via smartphone technology.

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Playback language: English
Abstract
This paper introduces a flexible and fully implantable wireless optoelectronic system for continuous and effective cancer treatment by combining photodynamic therapy (PDT) and hyperthermia, and enabling real-time tumor size monitoring. The system uses micro inorganic light-emitting diodes (µ-LEDs) emitting 624 nm light with programmable intensity and a Si phototransistor for tumor size monitoring. In vitro experiments, ray-tracing simulations, and in vivo studies using a tumor xenograft mouse model confirmed the system's superior capabilities in simultaneous cancer treatment and tumor size monitoring via wireless power and data transmission with a cell phone. This all-in-one system enables effective treatment of deep tumors and precise, continuous monitoring.
Publisher
npj Flexible Electronics
Published On
Aug 28, 2023
Authors
Kiho Kim, In Sik Min, Tae Hee Kim, Do Hyeon Kim, Seungwon Hwang, Kyowon Kang, Kyubeen Kim, Sangun Park, Jongmin Lee, Young Uk Cho, Jung Woo Lee, Woon-Hong Yeo, Young Min Song, Youngmee Jung, Ki Jun Yu
Tags
cancer treatment
photodynamic therapy
hyperthermia
real-time monitoring
wireless system
µ-LEDs
tumor size
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