Fractionated photoimmunotherapy stimulates an anti-tumour immune | ResearchBunny

Index

Abstract

Advanced epithelial ovarian cancer (EOC) has high recurrence rates. This study integrates in vitro measurements of EOC and T cell responses to chemotherapy, PDT, and EGFR-targeted PIT into a mathematical model of tumor-immune interaction. In vitro results showed that low light doses in PIT increased anti-tumor immune effector cells. Modeling demonstrated that fractionated PIT (multiple lower doses) could control tumors by stimulating an anti-tumor immune response. Further research is needed to optimize fractionated PIT dosimetry and timing.

Publisher

British Journal of Cancer

Published On

Sep 11, 2024

Authors

Mohammad U. Zahid, Matthew Waguespack, Rebecca C. Harman, Eric M. Kercher, Shubhankar Nath, Tayyaba Hasan, Imran Rizvi, Bryan Q. Spring, Heiko Enderling

Related Publications

Explore these studies to deepen your understanding of the subject.

Environmental Studies and Forestry

An integrated metagenomic and metabolite profiling study of hydrocarbon biodegradation and corrosion in navy ships

C. R. Marks, K. E. Duncan, et al.

Medicine and Health

Body composition, physical activity, and quality of life in pediatric patients with inflammatory bowel disease on anti-TNF therapy—an observational follow-up study

K. K. Boros, G. Veres, et al.

Chemistry

Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent *in vitro* anti-cancer properties

S. J. Allison, J. Bryk, et al.

Medicine and Health

Efficacy of BioMin F and NovaMin toothpastes against *streptococcus mutans*: an *in vitro* study

H. D. Alomari, Y. A. Tolibah, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny