Medicine and Health

Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study

M. U. Zahid, M. Waguespack, et al.

This research, conducted by Mohammad U. Zahid and colleagues, explores innovative approaches to combat advanced epithelial ovarian cancer (EOC) through mathematical modeling of tumor-immune interactions. By integrating in vitro measurements, they reveal how fractionated photodynamic therapy (PIT) can enhance anti-tumor immune responses, presenting a promising avenue for optimizing cancer treatment.

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Abstract

Advanced epithelial ovarian cancer (EOC) has high recurrence rates. This study integrates in vitro measurements of EOC and T cell responses to chemotherapy, PDT, and EGFR-targeted PIT into a mathematical model of tumor-immune interaction. In vitro results showed that low light doses in PIT increased anti-tumor immune effector cells. Modeling demonstrated that fractionated PIT (multiple lower doses) could control tumors by stimulating an anti-tumor immune response. Further research is needed to optimize fractionated PIT dosimetry and timing.

Publisher

British Journal of Cancer

Published On

Sep 11, 2024

Authors

Mohammad U. Zahid, Matthew Waguespack, Rebecca C. Harman, Eric M. Kercher, Shubhankar Nath, Tayyaba Hasan, Imran Rizvi, Bryan Q. Spring, Heiko Enderling

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