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Epithelial processed *Mycobacterium avium* subsp. *paratuberculosis* induced prolonged Th17 response and suppression of phagocytic maturation in bovine peripheral blood mononuclear cells

Veterinary Science

Epithelial processed *Mycobacterium avium* subsp. *paratuberculosis* induced prolonged Th17 response and suppression of phagocytic maturation in bovine peripheral blood mononuclear cells

H. Park, H. Park, et al.

Discover groundbreaking insights into Johne's disease as researchers, including Hong-Tae Park and his team, uncover how *Mycobacterium avium* subsp. *paratuberculosis* manipulates host immunity and lipid metabolism, leading to a prolonged Th17 response. This study reveals the complexities of host-MAP interactions through innovative transcriptomic analysis.

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Playback language: English
Abstract
Johne's disease (JD), caused by *Mycobacterium avium* subsp. *paratuberculosis* (MAP), is a chronic disease in ruminants. This study investigated host-MAP interactions using an epithelial passage model. Transcriptomic analysis of bovine PBMCs revealed that epithelial cell infection elicited a prolonged Th17 response (upregulation of IL-17A, IL-17F, and RORC). Global gene downregulation, especially in phagocytic cell surface receptors (Toll-like receptors and MHC class II molecules) and cholesterol efflux transporters, was observed. The findings suggest that MAP persists by manipulating host adaptive immunity and lipid metabolism in phagocytic cells.
Publisher
Scientific Reports
Published On
Dec 03, 2020
Authors
Hong-Tae Park, Hyun-Eui Park, Soojin Shim, Suji Kim, Min-Kyoung Shin, Han Sang Yoo
Tags
Johne's disease
*Mycobacterium avium*
host-MAP interactions
Th17 response
transcriptomic analysis
immunity
lipid metabolism

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