Medicine and Health

The role of peripheral white blood cell counts in the association between central adiposity and glycemic status

F. Liu, Y. Li, et al.

This study reveals a striking connection between central adiposity and diabetes risk, highlighting the mediating role of circulating white blood cell (WBC) counts. Findings from researchers Fengqiong Liu and colleagues in the Fuqing cohort study indicate that increased waist-to-hip ratios correlate with higher prediabetes and diabetes risk, with specific WBC types contributing to this association.

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Abstract

This cross-sectional study investigated the mediating role of circulating white blood cell (WBC) counts in the association between central adiposity and diabetes risk using data from 6,613 participants in the Fuqing cohort study. Results showed a positive association between waist-to-hip ratio (WHR) and prediabetes/diabetes risk. Elevated WBC counts were linked to both central adiposity and worsening glycemic status. Mediation analyses revealed significant indirect effects of central adiposity on prediabetes and diabetes risk through various WBC types (total WBC, neutrophils, lymphocytes, monocytes), suggesting that circulating WBC levels contribute to the mechanisms linking central adiposity and diabetes.

Publisher

Nutrition and Diabetes

Published On

May 17, 2024

Authors

Fengqiong Liu, Yanni Li, Wanxin Li, Ruimei Feng, Hongwei Zhao, Jun Chen, Shanshan Du, Weimin Ye

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