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Engineering probiotics to inhibit *Clostridioides difficile* infection by dynamic regulation of intestinal metabolism

Medicine and Health

Engineering probiotics to inhibit *Clostridioides difficile* infection by dynamic regulation of intestinal metabolism

E. Koh, I. Y. Hwang, et al.

This groundbreaking research by Elvin Koh, In Young Hwang, Hui Ling Lee, Ryan De Sotto, Jonathan Wei Jie Lee, Yung Seng Lee, John C. March, and Matthew Wook Chang unveils a novel therapeutic strategy targeting *Clostridioides difficile* infection through engineered probiotics. These innovative probiotics restore bile salt metabolism, effectively combating CDI and improving survival rates in mice, showcasing the powerful potential of microbiome modulation.

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