Food Science and Technology

Engineered plants provide a photosynthetic platform for the production of diverse human milk oligosaccharides

C. R. Barnum, B. Paviani, et al.

Discover how researchers Collin R. Barnum, Bruna Paviani, and their colleagues have harnessed the power of plants to produce diverse human milk oligosaccharides (HMOs). This groundbreaking study reveals that plant-based production is not only cheaper but also more scalable than traditional microbial methods, paving the way for a sustainable future in infant health.

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Abstract

Human milk oligosaccharides (HMOs) are diverse carbohydrates supporting infant health. Microbial production struggles to scale the ~200 HMOs. This study uses plants' robust carbohydrate anabolism to produce diverse HMOs, including complex ones like lacto-N-fucopentaose I. Plant-produced HMOs showed strong bifidogenic properties. Technoeconomic analyses suggest plant-based production is cheaper and more scalable than microbial methods, highlighting plants' potential for low-cost, sustainable HMO production.

Publisher

Nature Food

Published On

Jun 13, 2024

Authors

Collin R. Barnum, Bruna Paviani, Garret Couture, Chad Masarweh, Ye Chen, Yu-Ping Huang, Kasey Markel, David A. Mills, Carlito B. Lebrilla, Daniela Barile, Minliang Yang, Patrick M. Shih

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