Human milk oligosaccharides (HMOs) are diverse carbohydrates supporting infant health. Microbial production struggles to scale the ~200 HMOs. This study uses plants' robust carbohydrate anabolism to produce diverse HMOs, including complex ones like lacto-N-fucopentaose I. Plant-produced HMOs showed strong bifidogenic properties. Technoeconomic analyses suggest plant-based production is cheaper and more scalable than microbial methods, highlighting plants' potential for low-cost, sustainable HMO production.
Publisher
Nature Food
Published On
Jun 13, 2024
Authors
Collin R. Barnum, Bruna Paviani, Garret Couture, Chad Masarweh, Ye Chen, Yu-Ping Huang, Kasey Markel, David A. Mills, Carlito B. Lebrilla, Daniela Barile, Minliang Yang, Patrick M. Shih
Tags
human milk oligosaccharides
plant-based production
infant health
bifidogenic properties
sustainable production
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