Chemistry

Emergence of a short peptide based reductase via activation of the model hydride rich cofactor

A. Chatterjee, S. Goswami, et al.

This research showcases innovative short peptide-based amyloid nanotubes that effectively bind and reduce ester substrates in water using weak hydride transfer agents, demonstrating recyclability and controlled reduction. Conducted by Ayan Chatterjee, Surashree Goswami, Raushan Kumar, Janmejay Laha, and Dibyendu Das, the findings could reshape our understanding of protometabolism on early Earth.

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Abstract

This research demonstrates short peptide-based amyloid nanotubes that, through exposed cationic and hydrophobic residues, bind small molecular weak hydride transfer agents (like NaBH₄) to efficiently reduce ester substrates in water. These amyloid phases, loaded with borohydrides, show recyclability, substrate selectivity, and controlled reduction, surpassing the capabilities of reducing agents such as LiAlH₄. The findings suggest a potential role for short peptide-based assemblies in the emergence of protometabolism and biopolymer evolution on early Earth.

Publisher

Nature Communications

Published On

May 28, 2024

Authors

Ayan Chatterjee, Surashree Goswami, Raushan Kumar, Janmejay Laha, Dibyendu Das

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