Medicine and Health

The BNT162b2 mRNA COVID-19 Vaccine Increases the Contractile Sensitivity to Histamine and Parasympathetic Activation in a Human Ex Vivo Model of Severe Eosinophilic Asthma

A. Caputo, F. Nicoli, et al.

This study by Antonella Caputo and colleagues explores the acute effects of the BNT162b2 COVID-19 vaccine on severe eosinophilic asthma using an ex vivo model. The findings reveal that the vaccine enhances bronchial tone and responsiveness, offering insights into potential implications for asthmatic patients.

00:00

Playback language: English

Index

Abstract

This study investigated the acute impact of the BNT162b2 COVID-19 vaccine on a human ex vivo model of severe eosinophilic asthma. Passively sensitized human isolated bronchi were challenged with platelet-activating factor (PAF). BNT162b2 increased resting tone and response to histamine, shifting the concentration-response curve leftward and enhancing the response to electrical field stimulation (EFS). mRNA denaturation did not alter these effects, suggesting that the effect is due to an excipient, possibly polyethylene glycol (PEG), rather than the active component.

Publisher

Vaccines

Published On

Jan 28, 2023

Authors

Antonella Caputo, Francesco Nicoli, Luigino Calzetta, Alfredo Chetta, Marina Aiello, Annalisa Frizzelli, Josuel Ora, Enrico Melis, Francesco Facciolo, Lorenzo Ippoliti, Andrea Magrini, Paola Rogliani

Related Publications

Explore these studies to deepen your understanding of the subject.

Social Work

Evaluating the effectiveness of the Kidogo model in empowering women and strengthening their capacities to engage in paid labor opportunities through the provision of quality childcare: a study protocol for an exploratory study in Nakuru County, Kenya

K. Okelo, M. Nampijja, et al.

Political Science

The effect of Chinese vaccine diplomacy during COVID-19 in the Philippines and Vietnam: a multiple case study from a soft power perspective

R. J. L. V. Dijk and C. Y. Lo

Medicine and Health

Assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US

F. S, W. C, et al.

Social Work

Seeds and the city: a review of municipal home food gardening programs in Canada in response to the COVID-19 pandemic

J. Music, L. Mullins, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny