Medicine and Health

Effects of Mediterranean diet during pregnancy on the onset of overweight or obesity in the offspring: a randomized trial

S. Coppola, L. Paparo, et al.

The PREMEDI study reveals groundbreaking findings on the impact of a Mediterranean Diet during pregnancy, showing a significant reduction in the incidence of overweight or obesity in offspring at 24 months. This research, conducted by a team including Serena Coppola and Lorella Paparo, uncovers intriguing epigenetic modifications linked to dietary choices.

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Abstract

The PREMEDI study, a randomized controlled trial, investigated the efficacy of nutritional counseling promoting a Mediterranean Diet (MD) during pregnancy on the incidence of overweight or obesity in offspring at 24 months. Children of mothers in the MD arm had a significantly lower incidence of overweight or obesity (6% vs. 30%, p=0.003). Higher MD adherence was observed in the MD arm, with similar weight gain between groups. Cord blood analysis revealed a significantly higher leptin gene methylation rate in the MD group (p<0.0001), suggesting epigenetic modification of leptin expression plays a role.

Publisher

International Journal of Obesity

Published On

Sep 18, 2024

Authors

Serena Coppola, Lorella Paparo, Giorgio Bedogni, Rita Nocerino, Davide Costabile, Mariella Cuomo, Lorenzo Chiariotti, Laura Carucci, Annalisa Agangi, Marcello Napolitano, Francesco Messina, Annalisa Passariello, Roberto Berni Canani

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