The PREMEDI study, a randomized controlled trial, investigated the efficacy of nutritional counseling promoting a Mediterranean Diet (MD) during pregnancy on the incidence of overweight or obesity in offspring at 24 months. Children of mothers in the MD arm had a significantly lower incidence of overweight or obesity (6% vs. 30%, p=0.003). Higher MD adherence was observed in the MD arm, with similar weight gain between groups. Cord blood analysis revealed a significantly higher leptin gene methylation rate in the MD group (p<0.0001), suggesting epigenetic modification of leptin expression plays a role.
Publisher
International Journal of Obesity
Published On
Sep 18, 2024
Authors
Serena Coppola, Lorella Paparo, Giorgio Bedogni, Rita Nocerino, Davide Costabile, Mariella Cuomo, Lorenzo Chiariotti, Laura Carucci, Annalisa Agangi, Marcello Napolitano, Francesco Messina, Annalisa Passariello, Roberto Berni Canani
Tags
Mediterranean Diet
pregnancy
overweight
obesity
epigenetic modification
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