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Effectiveness of BA.1-and BA.4/BA. 5-Containing Bivalent COVID-19 mRNA Vaccines Against Symptomatic SARS-CoV-2 Infection During the BA.5-Dominant Period in Japan

Medicine and Health

Effectiveness of BA.1-and BA.4/BA. 5-Containing Bivalent COVID-19 mRNA Vaccines Against Symptomatic SARS-CoV-2 Infection During the BA.5-Dominant Period in Japan

T. Arashiro, Y. Arima, et al.

In a groundbreaking study conducted in Japan, researchers including Takeshi Arashiro and Yuzo Arima found that both BA.1-containing and BA.4/BA.5-containing bivalent mRNA vaccines showed high effectiveness against symptomatic COVID-19 infection during the BA.5-dominant period, outperforming monovalent vaccines and providing significant protection.

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Playback language: English
Abstract
In this multicenter, prospective, test-negative, case-control study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing bivalent coronavirus disease 2019 mRNA vaccines against symptomatic infection during the BA.5-dominant period was high compared with no vaccination (65% and 76%) and moderate compared with monovalent vaccines administered over half a year earlier (46% combined).
Publisher
Open Forum Infectious Diseases
Published On
May 03, 2023
Authors
Takeshi Arashiro, Yuzo Arima, Jin Kuramochi, Hirokazu Muraoka, Akihiro Sato, Kumi Chubachi, Atsushi Yanai, Hiroko Arioka, Yuki Uehara, Genei Ihara, Yasuyuki Kato, Naoki Yanagisawa, Akihiro Ueda, Hideaki Kato, Hideaki Oka, Yusuke Nishida, Yuki Nidaira, Takahiro Asami, Torahiko Jinta, Akira Nakamura, Kunihiro Oba, Daisuke Taniyama, Kei Yamamoto, Katsushi Tanaka, Kankuro Ueshima, Tetsuji Fuwa, Ashley Stucky, Tadaki Suzuki, Chris Smith, Martin Hibberd, Koya Ariyoshi, Motoi Suzuki
Tags
COVID-19
vaccines
mRNA
symptomatic infection
BA.5
effectiveness
Japan

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