This study investigated the impact of social environment on wild-type (WT) and Shank3 knockout (KO) mice, a model of autism. Chronic social isolation enhanced social interaction and olfactory neuron responses in WT mice and restored impairments in Shank3 KO mice. Enriched social environments differently affected WT and Shank3 KO mice. Findings suggest potential for behavioral interventions and inclusive classroom programs for children with ASD.
Publisher
Translational Psychiatry
Published On
Nov 07, 2024
Authors
Caroline Gora, Ana Dudas, Lucas Court, Anil Annamneedi, Gaëlle Lefort, Thiago S. Nakahara, Nicolas Azzopardi, Adrien Acquistapace, Anne-Lyse Laine, Anne-Charlotte Trouillet, Lucile Drobecq, Emmanuel Pecnard, Benoît Piégu, Pascale Crépieux, Pablo Chamero, Lucie P. Pellissier
Tags
social environment
wild-type mice
Shank3 knockout
autism
behavioral interventions
social interaction
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