Psychology

Effect of the social environment on olfaction and social skills in wild-type and a mouse model of autism

C. Gora, A. Dudas, et al.

This fascinating study by Caroline Gora and colleagues explores how social environments impact both wild-type and Shank3 knockout mice, shedding light on potential behavioral interventions for autism. Discover how social isolation and enriched environments shape interactions and responses, offering hope for children with ASD.

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Playback language: English

Index

Abstract

This study investigated the impact of social environment on wild-type (WT) and Shank3 knockout (KO) mice, a model of autism. Chronic social isolation enhanced social interaction and olfactory neuron responses in WT mice and restored impairments in Shank3 KO mice. Enriched social environments differently affected WT and Shank3 KO mice. Findings suggest potential for behavioral interventions and inclusive classroom programs for children with ASD.

Publisher

Translational Psychiatry

Published On

Nov 07, 2024

Authors

Caroline Gora, Ana Dudas, Lucas Court, Anil Annamneedi, Gaëlle Lefort, Thiago S. Nakahara, Nicolas Azzopardi, Adrien Acquistapace, Anne-Lyse Laine, Anne-Charlotte Trouillet, Lucile Drobecq, Emmanuel Pecnard, Benoît Piégu, Pascale Crépieux, Pablo Chamero, Lucie P. Pellissier

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