Medicine and Health

Cortical structure and the risk for Alzheimer’s disease: a bidirectional Mendelian randomization study

B. Wu, Y. Zhang, et al.

This groundbreaking study by Bang-Sheng Wu and colleagues explores the intriguing link between brain structure and Alzheimer's disease risk. It reveals suggestive associations of cortical surface area alterations, exciting the field with potential new insights into vulnerability factors for AD.

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Abstract

This study investigated the causal relationship between cortical structure (surface area and thickness) and Alzheimer's disease (AD) risk using a bidirectional two-sample Mendelian randomization analysis. Suggestive associations were found between decreased surface area of the temporal pole and cuneus, and increased AD risk. Conversely, decreased surface area of the precentral and insular cingulate were suggestively associated with increased AD vulnerability. However, none of the Bonferroni-corrected p-values reached significance.

Publisher

Translational Psychiatry

Published On

Nov 01, 2021

Authors

Bang-Sheng Wu, Ya-Ru Zhang, Hong-Qi Li, Kevin Kuo, Shi-Dong Chen, Qiang Dong, Yong Liu, Jin-Tai Yu

DOI

https://doi.org/10.1038/s41398-021-01599-x

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