Individuals with pacemakers are at increased risk of left ventricular systolic dysfunction (LVSD). A multicenter controlled trial (OPT-PACE) randomized 1,201 pacemaker patients to echocardiography screening or usual care. LVSD (LVEF <50%) was detected in 34% of the screening arm. The primary outcome (time to first HF hospitalization or death) showed no significant difference between groups (hazard ratio = 0.89; 95% CI = 0.69, 1.17). Exploratory analysis suggested improved outcomes in patients with LVSD managed by a specialist clinic. Echocardiography screening commonly identifies LVSD but alone doesn't improve outcomes; specialized clinic management may offer benefit.
Publisher
Nature Medicine
Published On
Nov 01, 2024
Authors
Maria F. Paton, John Gierula, Haqeel A. Jamil, Sam Straw, Judith E. Lowry, Rowena Byrom, Thomas A. Slater, Alasdair M. Fellows, Richard G. Gillott, Hemant Chumun, Paul Smith, Richard M. Cubbon, Deborah D. Stocken, Mark T. Kearney, Klaus K. Witte
Tags
pacemakers
left ventricular systolic dysfunction
echocardiography
HF hospitalization
specialist clinic management
multicenter trial
health outcomes
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