Does Minimed 780G™ Insulin Pump System Affect Energy and Nutrient Intake?: Long-Term Follow-up Study

Objective: To evaluate the energy and nutrient intake of children, adolescents, and young adults with type 1 diabetes (T1D) who started using automated insulin delivery (AID) systems (MiniMed 780G™) before transition and during 6-month follow-up in a real-world setting. Research Design and Methods: Twenty-nine people with T1D completed 3-day food diaries and had glycemic outcomes analyzed at baseline and at the 3rd and 6th months after switching to an advanced hybrid closed-loop system (a-HCL). Results: Mean carbohydrate, protein, and fat intake (energy %) at baseline were 49.1 ± 4.5, 17.8 ± 2.3, and 33.0 ± 3.9, respectively, with no statistically significant differences over follow-up. Fiber intake remained low (<14 g/1000 kcal) and saturated fat intake remained high (>10% energy) at baseline and follow-up. The median auto-correction bolus ratio increased from 14.0 (9.5)% after 14 days in auto mode to 18.0 (11.0)% at 3 months and 19.0 (7.5)% at 6 months (p < 0.05). Auto-correction boluses correlated negatively with time in range (TIR) at 3 months (r = -0.747, p < 0.01) and 6 months (r = -0.395, p < 0.05). Conclusions: Advanced hybrid closed-loop systems offer better glycemic control. Use of the MiniMed 780G™ did not change energy and nutrient intake. This real-world study suggests children, adolescents, and young adults with T1D consume saturated fat above and fiber below recommendations, independent of a-HCL use. ClinicalTrials.gov registration: NCT05666596.

Yasemin Atik-Altinok, Yelda Mansuroglu, Gunay Demir, Hanife Gul Balki, Samim Ozen, Sukran Darcan, Damla Goksen