Medicine and Health

DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune response

E. Oktay, F. Alem, et al.

This groundbreaking research by Esra Oktay, Farhang Alem, Keziah Hernandez, Michael Girgis, Christopher Green, Divita Mathur, Igor L. Medintz, Aarthi Narayanan, and Remi Veneziano reveals that DNA origami nanoparticles displaying multiple copies of a SARS-CoV-2 receptor binding domain trigger a strong immune response in mice, paving the way for innovative and effective vaccines.

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Abstract

This research demonstrates that DNA origami nanoparticles (DNA-NPs) presenting ten copies of a reconstituted SARS-CoV-2 receptor binding domain (RBD) trimer, along with CpG adjuvants, elicit a robust protective immune response in mice. The DNA-NP approach shows potential for developing safe and effective vaccines with a prolonged antibody response and effective protection against viral challenge.

Publisher

COMMUNICATIONS BIOLOGY

Published On

Mar 23, 2023

Authors

Esra Oktay, Farhang Alem, Keziah Hernandez, Michael Girgis, Christopher Green, Divita Mathur, Igor L. Medintz, Aarthi Narayanan, Remi Veneziano

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