Medicine and Health

Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes

A. Citro, A. Neroni, et al.

This groundbreaking research proposes using decellularized lungs as scaffolds for xenogeneic vascularized endocrine pancreas engineering, combining neonatal porcine islets with human endothelial cells. Conducted by a team from the San Raffaele Diabetes Research Institute in Milan, this study reveals promising results in islet maturation and sustained normoglycemia, paving the way for advanced diabetes treatments.

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Abstract

Intrahepatic islet transplantation is the standard cell therapy for β cell replacement in type 1 diabetes, but limitations include donor shortage and poor engraftment. This study proposes a novel approach using decellularized lung as a scaffold, seeded with neonatal porcine islets and human blood outgrowth endothelial cells, to engineer a xenogeneic vascularized endocrine pancreas (VEP). Ex vivo and in vivo studies demonstrate improved islet maturation and function, with sustained normoglycemia in a preclinical model for over 18 weeks. This technology, combined with advancements in pig genetic engineering, holds promise for creating immune-protected functional endocrine organs.

Publisher

Nature Communications

Published On

Feb 16, 2023

Authors

Antonio Citro, Alessia Neroni, Cataldo Pignatelli, Francesco Campo, Martina Policardi, Matteo Monieri, Silvia Pellegrini, Erica Dugnani, Fabio Manenti, Maria Chiara Maffia, Libera Valla, Elisabeth Kemter, Ilaria Marzinotto, Cristina Olgasi, Alessia Cucci, Antonia Follenzi, Vito Lampasona, Eckhard Wolf, Lorenzo Piemonti

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