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The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk

Medicine and Health

The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk

A. Lang, O. Kuss, et al.

This research delves into the complex relationship between sucrose intake and the onset of diabetes, highlighting intriguing contrasts between self-reported and biomarker data. Conducted by prominent researchers including Alexander Lang and Oliver Kuss, this study uncovers how obesity plays a significant mediating role in this association.

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Playback language: English
Abstract
This study investigated the association between sucrose intake (self-reported and urinary biomarker) and incident diabetes, considering obesity's mediating role. Using data from a sub-cohort (n=2996) of the EPIC-Norfolk study, inverse associations were found between self-reported sucrose intake and diabetes incidence. However, urinary sucrose showed a positive association with incident diabetes. Mediation analysis revealed that BMI and waist circumference mediated 16% and 22% of this association, respectively. Further research using objective biomarkers is needed.
Publisher
Nutrition & Diabetes
Published On
Sep 02, 2023
Authors
Alexander Lang, Oliver Kuss, Tim Filla, Gunter Kuhnle, Sabrina Schlesinger
Tags
sucrose intake
diabetes incidence
urinary biomarker
obesity
BMI
waist circumference
epidemiology

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