Development of a novel testis-on-a-chip that demonstrates | ResearchBunny

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Abstract

This research paper details the development of a 3D multicellular testis-on-a-chip platform that accurately replicates the reciprocal crosstalk between Sertoli and Leydig cells, crucial for spermatogenesis. The platform incorporates various human testicular tissue cells and natural polymers with blood coagulation factors. SERPINB2 is identified as a biomarker for male reproductive toxicity, and a fluorescent reporter system is integrated to assess material toxicity. This testis-on-a-chip model offers advancements in toxicity screening and reproductive research.

Publisher

Experimental & Molecular Medicine

Published On

Jul 01, 2024

Authors

Se-Ra Park, Myung Geun Kook, Soo-Rim Kim, Choon-Mi Lee, Jin Woo Lee, Jung-Kyu Park, Chan Hum Park, Byung-Chul Oh, YunJae Jung, In-Sun Hong

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