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Abstract
Canine parvovirus (CPV) is a significant pathogen. To understand the immune response to vaccination, researchers purified polyclonal antibodies from vaccinated dogs and used cryo-EM to determine the high-resolution structures of polyclonal Fab-virus complexes. Analysis revealed five distinct Fabs, all of which interfere with receptor binding, suggesting a focused and potentially redundant neutralizing antibody response.
Publisher
Communications Biology
Published On
Sep 19, 2023
Authors
Samantha R. Hartmann, Andrew J. Charnesky, Simon P. Früh, Robert A. López-Astacio, Wendy S. Weichert, Nadia DiNunno, Sung Hung Cho, Carol M. Bator, Colin R. Parrish, Susan L. Hafenstein
Tags
canine parvovirus
vaccination
immune response
polyclonal antibodies
neutralizing antibodies
cryogenic electron microscopy

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