Veterinary Science

Links between fecal microbiota and the response to vaccination against influenza A virus in pigs

M. Borey, F. Blanc, et al.

This groundbreaking study, conducted by Marion Borey and colleagues, unveils fascinating links between the fecal microbiota of pigs and their varied responses to influenza A virus vaccines. Discover how specific microbial populations could enhance vaccine efficacy, leading to stronger immune responses in livestock.

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Abstract

This study investigated the associations between fecal microbiota and vaccine response variability in pigs. 98 piglets were vaccinated against influenza A virus (IAV), and their immune response was measured via serum IAV-specific IgG and hemagglutination inhibition (HAI) assays. Pre-vaccination microbiota analysis revealed a correlation between richer microbiota and a stronger vaccine response. 23 operational taxonomic units (OTUs) showed differential abundance between high and low IgG producers. *Prevotella* and *Muribaculaceae* were linked to stronger responses, while *Helicobacter* and *Escherichia-Shigella* were associated with weaker responses. A set of 81 OTUs accurately predicted IgG and HAI levels at all time points, demonstrating early and late associations between pre-vaccination microbiota and immune response.

Publisher

npj Vaccines

Published On

Jul 22, 2021

Authors

Marion Borey, Fany Blanc, Gaëtan Lemonnier, Jean-Jacques Leplat, Deborah Jardet, Marie-Noëlle Rossignol, Laure Ravon, Yvon Billon, Maria Bernard, Jordi Estellé, Claire Rogel-Gaillard

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