Veterinary Science

Cryo EM structures map a post-vaccination polyclonal antibody response to canine parvovirus

S. R. Hartmann, A. J. Charnesky, et al.

Explore the fascinating findings on canine parvovirus vaccination responses! Researchers, including Samantha R. Hartmann and Andrew J. Charnesky, have uncovered five unique antibodies that not only show promise in neutralizing the virus but also suggest a resilient immune response. Discover how these revelations can impact canine health!

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Abstract

Canine parvovirus (CPV) is a significant pathogen. To understand the immune response to vaccination, researchers purified polyclonal antibodies from vaccinated dogs and used cryo-EM to determine the high-resolution structures of polyclonal Fab-virus complexes. Analysis revealed five distinct Fabs, all of which interfere with receptor binding, suggesting a focused and potentially redundant neutralizing antibody response.

Publisher

Communications Biology

Published On

Sep 19, 2023

Authors

Samantha R. Hartmann, Andrew J. Charnesky, Simon P. Früh, Robert A. López-Astacio, Wendy S. Weichert, Nadia DiNunno, Sung Hung Cho, Carol M. Bator, Colin R. Parrish, Susan L. Hafenstein

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