This study investigated the impact of inactivated COVID-19 vaccines on the immune response of recovered COVID-19 patients. The results showed that vaccination significantly boosted both humoral and cellular immunity, increasing antibody titers and neutralizing activity against various SARS-CoV-2 variants, including Delta and Omicron, for up to 9 months. While the humoral response decreased over time, and Omicron showed more resistance to neutralization, vaccination still enhanced the overall immune response, providing protection against reinfection.
Publisher
Cell Discovery
Published On
Authors
Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu, Yan Peng, Zhijun Zhou, Tao Deng, Jing Liu, Deming Ji, Ran Qi, Lianzhen Lin, Yan Zeng, Fei Xia, Yong Hu, Taojing Li, Kai Duan, Xingou Li, Zejun Wang, Yong Zhang, Huang Zhang, Chen Zhu, Shang Wang, Xiao Wu, Xiang Wang, Yuwei Li, Shihe Huang, Min Mao, Huanhuan Guo, Yunkai Yang, Rui Jia, Jingwei Xufang, Xuewei Wang, Shuyan Liang, Zhixin Qiu, Juan Zhang, Yaling Ding, Chunyan Li, Jin Zhang, Daoxing Fu, Yanlin He, Dongbo Zhou, Cesheng Li, Jiayou Zhang, Xiao-Ming Yang
Tags
COVID-19
vaccines
immune response
SARS-CoV-2
neutralization
reinfection
variant resistance
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