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Abstract
This 2-year longitudinal PET study investigated the progression of [18F]-flortaucipir binding and cortical atrophy in Alzheimer's disease (AD) patients and their relationship with cognitive decline. Twenty-seven AD patients and twelve amyloid-negative controls underwent neuropsychological assessments, brain MRI, and [18F]-flortaucipir PET imaging at baseline and annually for two years. Results showed varied tau SUVr progression patterns depending on initial temporoparietal tau load. High-Tau1 patients exhibited frontal SUVr increases, temporoparietal decreases, and rapid clinical decline, while low-Tau1 patients showed increases across all regions and slower decline. Cognitive decline correlated strongly with cortical atrophy but weakly with SUVr progression. Tau-PET could identify patients with more aggressive clinical courses.
Publisher
Alzheimer's Research & Therapy
Published On
Jul 26, 2023
Authors
Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Sébastian Rodrigo, Philippe Gervais, Fabien Caillé, Martin Moussion, Michel Bottlaender, Marie Sarazin
Tags
Alzheimer's disease
tau binding
cortical atrophy
PET study
cognitive decline
neuropsychological assessments
longitudinal study

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