Medicine and Health

Combined associations of 25-hydroxivitamin D and parathyroid hormone with diabetes risk and associated comorbidities among U.S. white and black women

J. Xia, W. Tu, et al.

This intriguing study reveals how levels of 25-hydroxyvitamin D and parathyroid hormone can significantly influence diabetes risk and related health issues among postmenopausal women. Conducted by a team of experts, it highlights the critical role of vitamin D in preventing diabetes, particularly in white women, regardless of parathyroid hormone levels.

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Abstract

This study investigated the combined associations of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) with diabetes risk and related comorbidities in white and black postmenopausal women. Lower 25(OH)D and higher PTH were linked to higher hypertension prevalence in white women. Vitamin D deficiency and PTH excess were associated with increased prevalence of CKD, hypertension, or obesity in non-diabetic women. Prospectively, lower 25(OH)D was associated with lower diabetes incidence in white women, with vitamin D deficiency increasing diabetes risk regardless of PTH levels.

Publisher

Nutrition and Diabetes

Published On

Sep 16, 2021

Authors

Jin Xia, Wanzhu Tu, JoAnn E. Manson, Hongmei Nan, Aladdin H. Shadyab, Jennifer W. Bea, Emily W. Gower, Lihong Qi, Ting-Yuan David Cheng, Yiqing Song

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