This study investigated post-acute sequelae of SARS-CoV-2 infection (PASC) using electronic health record data from 63,675 patients. A case-control design and phenome-wide association studies characterized PASC-associated diagnoses across pre-, acute-, and post-COVID-19 periods. Phenotype risk scores (PheRSs) were developed and evaluated for predictive performance. Results showed enrichment of known PASC symptoms and other disorders in the post-COVID-19 period. Pre- and acute-COVID-19 PheRSs effectively stratified risk, identifying a subset with a 3.5-fold increased PASC risk. The study highlights the complex interplay of predisposing and presenting features in PASC, suggesting potential for risk stratification.
Publisher
Journal of Clinical Medicine
Published On
Feb 07, 2023
Authors
Lars G Fritsche, Weijia Jin, Andrew J Admon, Bhramar Mukherjee
Tags
PASC
SARS-CoV-2
electronic health records
risk stratification
phenotype risk scores
post-COVID-19 symptoms
case-control design
Related Publications
Explore these studies to deepen your understanding of the subject.
