Medicine and Health

Characterizing and Predicting Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in a Large Academic Medical Center in the US

L. G. Fritsche, W. Jin, et al.

This groundbreaking study by Lars G Fritsche, Weijia Jin, Andrew J Admon, and Bhramar Mukherjee delves into post-acute sequelae of SARS-CoV-2 infection, revealing a complex interplay of symptoms and disorders that emerge after COVID-19. Utilizing data from over 63,000 patients, the research underscores the potential for effective risk stratification based on pre-existing conditions and acute symptoms.

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Abstract

This study investigated post-acute sequelae of SARS-CoV-2 infection (PASC) using electronic health record data from 63,675 patients. A case-control design and phenome-wide association studies characterized PASC-associated diagnoses across pre-, acute-, and post-COVID-19 periods. Phenotype risk scores (PheRSs) were developed and evaluated for predictive performance. Results showed enrichment of known PASC symptoms and other disorders in the post-COVID-19 period. Pre- and acute-COVID-19 PheRSs effectively stratified risk, identifying a subset with a 3.5-fold increased PASC risk. The study highlights the complex interplay of predisposing and presenting features in PASC, suggesting potential for risk stratification.

Publisher

Journal of Clinical Medicine

Published On

Feb 07, 2023

Authors

Lars G Fritsche, Weijia Jin, Andrew J Admon, Bhramar Mukherjee

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