Medicine and Health

Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial

K. Mautner, M. Gottschalk, et al.

Discover groundbreaking insights from a phase 2/3 randomized controlled trial that compares innovative cell therapies with corticosteroid injections for knee osteoarthritis, led by an expert team including Ken Mautner, Michael Gottschalk, and Scott D. Boden. This study reveals that, after one year, these advanced treatments did not outperform conventional corticosteroids in alleviating pain or enhancing function.

00:00

Playback language: English

Index

Abstract

This phase 2/3 randomized controlled trial compared three types of cell injections (autologous bone marrow aspirate concentrate, autologous adipose stromal vascular fraction, and allogeneic human umbilical cord tissue-derived mesenchymal stromal cells) to corticosteroid injection for knee osteoarthritis. At 1 year, none of the cell therapies showed superiority over corticosteroid injection in reducing pain or improving function, based on visual analog scale and Knee injury and osteoarthritis outcome score pain scores. No serious adverse events were reported.

Publisher

Nature Medicine

Published On

Dec 29, 2023

Authors

Ken Mautner, Michael Gottschalk, Scott D. Boden, Alison Akard, Won C. Bae, Lora Black, Blake Boggess, Paramita Chatterjee, Christine B. Chung, Kirk A. Easley, Greg Gibson, Josh Hackel, Katie Jensen, Linda Kippner, Chad Kurtenbach, Joanne Kurtzberg, R. Amadeus Mason, Benjamin Noonan, Krishnendu Roy, Verle Valentine, Carolyn Yeago, Hicham Drissi

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial

A. H. Diacon, C. E. B. Iii, et al.

Medicine and Health

Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial

M. Schuler, K. Cuppens, et al.

Psychology

Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial

R. D. Woodham, S. Selvaraj, et al.

Medicine and Health

Analgesic Effect of Low-Level Laser Therapy before Heel Lance for Pain Management in Healthy Term Neonates: A Randomized Controlled Trial

B. Wu, M. Ou-yang, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny