Medicine and Health

Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCESO1 trial

J. Qin, L. Xue, et al.

This groundbreaking phase 3 trial evaluates the combination of neoadjuvant camrelizumab with chemotherapy against chemotherapy alone in patients with locally advanced esophageal squamous cell carcinoma. Notably, it demonstrates superior pathological complete response rates, paving the way for innovative treatment options. The research was conducted by an extensive team of experts from leading institutions.

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Abstract

This multicenter, randomized, open-label phase 3 trial assessed the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy followed by adjuvant camrelizumab versus neoadjuvant chemotherapy alone in 391 patients with resectable locally advanced esophageal squamous cell carcinoma. The Cam+nab-TP and Cam+TP groups (camrelizumab with either albumin-bound paclitaxel and cisplatin or paclitaxel and cisplatin) showed significantly higher pathological complete response (PCR) rates (28.0% and 15.4%, respectively) than the TP group (4.7%). The safety profile was tolerable. Event-free survival data were not yet mature.

Publisher

Nature Medicine

Published On

Sep 01, 2024

Authors

Jianjun Qin, Liyan Xue, Anlin Hao, Xiaofeng Guo, Tao Jiang, Yunfeng Ni, Shuoyan Liu, Yujie Chen, Hongjing Jiang, Chen Zhang, Mingqiang Kang, Jihong Lin, Hecheng Li, Chengqiang Li, Hui Tian, Lin Li, Junke Fu, Yong Zhang, Jianqun Ma, Xiaoyuan Wang, Maoyong Fu, Hao Yang, Zhaoyang Yang, Yongtao Han, Longqi Chen, Lijie Tan, Tianyang Dai, Yongde Liao, Weiguo Zhang, Bin Li, Qixun Chen, Shiping Guo, Yu Qi, Li Wei, Zhigang Li, Ziqiang Tian, Xiaozheng Kang, Ruixiang Zhang, Yong Li, Zhen Wang, Xiankai Chen, Zhiguo Hou, Rongrong Zheng, Wenqing Zhu, Jie He, Yin Li

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