Psychology

Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial

R. D. Woodham, S. Selvaraj, et al.

Discover how a 10-week home-based tDCS treatment significantly alleviated depressive symptoms in 174 participants as evidenced in a randomized trial. Conducted by a team of researchers from the University of East London and McGovern Medical School, the study showcases high efficacy and safety, heralding a new approach to managing Major Depressive Disorder.

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Abstract

This fully remote, multisite, double-blind, placebo-controlled, randomized superiority trial investigated the efficacy of a 10-week home-based tDCS treatment for MDD. 174 participants (120 women, 54 men) were randomized to active (n=87) or sham (n=87) treatment. Active tDCS (2 mA) showed significantly greater improvement in depressive symptoms (HDRS) than sham (0 mA) (95% CI = 0.51-4.01, P=0.012). The 10-week home-based tDCS treatment demonstrated high efficacy, acceptability, and safety.

Publisher

Nature Medicine

Published On

Oct 21, 2024

Authors

Rachel D. Woodham, Sudhakar Selvaraj, Nahed Lajmi, Harriet Hobday, Gabrielle Sheehan, Ali-Reza Ghazi-Noori, Peter J. Lagerberg, Maheen Rizvi, Sarah S. Kwon, Paulette Orhii, David Maislin, Lucia Hernandez, Rodrigo Machado-Vieira, Jair C. Soares, Allan H. Young, Cynthia H. Y. Fu

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