Chronic stress is a major risk factor for depression. This study investigated the combined effects of physical exercise (PE) and cannabinoid type 2 receptor (CB2R) modulation on adult hippocampal neurogenesis (AHN) and behavior in chronically stressed mice. CB2R inhibition, but not activation, combined with PE significantly improved stress-induced emotional and cognitive deficits. This improvement correlated with increased cell proliferation and differentiation of newborn neurons, reduced neuroinflammation, and increased hippocampal BDNF levels. The findings suggest that CB2R inhibition enhances the antidepressant and neurogenic effects of PE after chronic stress, highlighting a potential therapeutic strategy for stress-related disorders.
Publisher
Translational Psychiatry
Published On
Mar 30, 2024
Authors
R. S. Rodrigues, J. B. Moreira, J. M. Mateus, A. Barateiro, S. L. Paulo, S. H. Vaz, D. M. Lourenço, F. F. Ribeiro, R. Soares, E. Loureiro-Campos, P. Bielefeld, A. M. Sebastião, A. Fernandes, L. Pinto, C. P. Fitzsimons, S. Xapelli
Tags
chronic stress
depression
physical exercise
cannabinoid receptors
neurogenesis
BDNF
mice
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