Medicine and Health

Impact of the Remission of Type 2 Diabetes on Cardiovascular Structure and Function, Exercise Capacity and Risk Profile: A Propensity Matched Analysis

J. M. Bilak, J. L. Yeo, et al.

This innovative research investigates the effects of Type 2 diabetes remission on cardiovascular health, revealing a striking link between remission and improved metabolic risk profiles. Conducted by a team from the University of Leicester, the findings highlight the persistent need for risk factor control even in remission cases.

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Abstract

Type 2 diabetes (T2D) significantly increases heart failure risk, often showing cardiovascular abnormalities before symptoms. This study investigated the impact of T2D remission on cardiovascular structure and function, exercise capacity, and risk profile. Adults with T2D without cardiovascular disease underwent cardiovascular imaging, cardiopulmonary exercise testing, and cardiometabolic profiling. T2D remission cases (HbA1c < 6.5% without glucose-lowering therapy for ≥3 months) were propensity score matched to those with active T2D and non-T2D controls. T2D remission was linked to a better metabolic risk profile and ventilatory response to exercise but not to improvements in cardiovascular structure or function. Concentric remodeling persisted in remission. Continued risk factor control is crucial for this patient group.

Publisher

Journal of Cardiovascular Development and Disease

Published On

Apr 24, 2023

Authors

Joanna M Bilak, Jian L Yeo, Gaur S Gulsin, Anna-Marie Marsh, Manjit Sian, Abhishek Datta, Sarah L Ayton, Kelly S Parke, Moira Bain, Wenjie Pang, Sherif Boulos, Tim G St Pierre, Melanie J Davies, Thomas Yates, Gerry P Mccann, Emer M Brady

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