Medicine and Health

Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress

R. S. Rodrigues, J. B. Moreira, et al.

This groundbreaking study by R. S. Rodrigues and colleagues reveals that inhibiting cannabinoid type 2 receptors enhances the antidepressant effects of physical exercise in mice facing chronic stress. The research highlights significant improvements in emotional and cognitive functions, suggesting a promising therapeutic avenue for stress-related disorders.

00:00

Playback language: English

Index

Abstract

Chronic stress is a major risk factor for depression. This study investigated the combined effects of physical exercise (PE) and cannabinoid type 2 receptor (CB2R) modulation on adult hippocampal neurogenesis (AHN) and behavior in chronically stressed mice. CB2R inhibition, but not activation, combined with PE significantly improved stress-induced emotional and cognitive deficits. This improvement correlated with increased cell proliferation and differentiation of newborn neurons, reduced neuroinflammation, and increased hippocampal BDNF levels. The findings suggest that CB2R inhibition enhances the antidepressant and neurogenic effects of PE after chronic stress, highlighting a potential therapeutic strategy for stress-related disorders.

Publisher

Translational Psychiatry

Published On

Mar 30, 2024

Authors

R. S. Rodrigues, J. B. Moreira, J. M. Mateus, A. Barateiro, S. L. Paulo, S. H. Vaz, D. M. Lourenço, F. F. Ribeiro, R. Soares, E. Loureiro-Campos, P. Bielefeld, A. M. Sebastião, A. Fernandes, L. Pinto, C. P. Fitzsimons, S. Xapelli

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Effects of semaglutide with and without concomitant SGLT2 inhibitor use in participants with type 2 diabetes and chronic kidney disease in the FLOW trial

J. F. E. Mann, P. Rossing, et al.

Medicine and Health

Impact of the Remission of Type 2 Diabetes on Cardiovascular Structure and Function, Exercise Capacity and Risk Profile: A Propensity Matched Analysis

J. M. Bilak, J. L. Yeo, et al.

Medicine and Health

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

J. Yang, S. J. L. Petitjean, et al.

Medicine and Health

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)

A. J. M. Aabakke, T. G. Petersen, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny