Medicine and Health

Physical exercise mediates a cortical FMRP-mTOR pathway to improve resilience against chronic stress in adolescent mice

L. Yan, M. Wang, et al.

Discover how treadmill exercise can combat anxiety in adolescent mice! This study by Lan Yan, Mei Wang, Fengzhen Yang, Yajie Wang, Siqi Wang, Kwok-Fai So, and Li Zhang reveals the intriguing molecular mechanisms at play, highlighting the role of the FMRP-mTOR pathway in enhancing stress resilience. Tune in to explore the connection between exercise and mental health.

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Abstract

This study investigated the molecular mechanism of exercise-mediated anxiolysis in adolescent mice using a chronic restraint stress (CRS) model. Fourteen days of treadmill exercise maintained normal neural activity and axonal myelination in the medial prefrontal cortex (mPFC), preventing anxiety-like behaviors. Exercise activated the mTOR pathway in the mPFC, with upstream inhibition of Fragile X mental retardation protein (FMRP) expression via RNA methylation. In summary, treadmill exercise modulates the FMRP-mTOR pathway to improve stress resilience.

Publisher

Translational Psychiatry

Published On

Jan 19, 2023

Authors

Lan Yan, Mei Wang, Fengzhen Yang, Yajie Wang, Siqi Wang, Kwok-Fai So, Li Zhang

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